Foreign-body granulomas within intramyocardial arteries in a transcoronary safety assessment in pigs
Foreign-body granulomas within intramyocardial arteries were detected in three domestic pigs (Sus scrofa domestica) in a routine transcoronary safety assessment study. The foreign bodies stained light grayish-blue by hematoxylin and eosin (H&E) and were strongly birefringent by polarized light microscopy. By their morphological features, they were identified as cotton fibers. Embolization of foreign-body material into the myocardial arteries following catheter-based procedure
Electrocoating of stainless steel coronary stents for extended release of paclitaxel
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel Department of Inorganic and Analytical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel Expert in Toxicologic Pathology, Sackler School of Medicine, Tel Aviv University, Timrat 36576, Israel AQ2 National Institute for Pharmaceutical Research (NIPER), New Delhi, India Abstract: Nonbiodegradable polyme
Gentamicin extended release from an injectable polymeric implant.
Author information Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel. Abstract Gentamicin sulfate, a potent antibiotic agent, is currently used for treatment of osteomyelitis mainly by intravenous injection with a long-term indwelling catheter, local implant of antibiotic containing polymethylmethacrylate beads or calcium phosphate (bone cements). Searching for more effective treatments, thi
Systemic imbalance of essential metals and cardiac gene expression in rats following acute pulmonary
Author information Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA. Abstract It was recently demonstrated that particulate matter (PM) containing water-soluble zinc produces cardiac injury following pulmonary exposure. To investigate whether pulmonary zinc exposure produces systemic metal imbalance and direct cardiac effects, male Wistar Kyoto (WKY) rats (12-14 wk age) were intratra
Biocompatibility of the Ex-PRESS Miniature Glaucoma Drainage Implant
*Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, †Goldshleger Eye Research Institute, Tel Aviv University, Tel Hashomer, Israel, and ‡Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Abstract Purpose: Based on lessons learned from earlier attempts, a novel miniature glaucoma implant, Ex-PRESS, was developed in 1998. The current study summarizes the histopathologic evaluation o