Treatment of osteomyelitis in rats by injection of degradable polymer releasing gentamicin.
Author information Department of Orthopaedic Surgery, Meir Medical Center, 48 Tchernichovsky Str., Kfar-Saba 44281, Israel. yaronbrin@gmail.com Abstract We evaluated the potential of an injectable degradable polymer-poly(sebacic-co-ricinoleic-ester-anhydride) containing gentamicin for the treatment of osteomyelitis. Osteomyelitis of both tibiae was induced in 13 female Fischer rats by injecting a suspension containing approximately 105 (CFU)/ml of S. aureus into the tibial me