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Author information

  1. a Curriculum in Toxicology , University of North Carolina School of Medicine , Chapel Hill , North Carolina , USA.

Abstract

 

In former mine workers of Libby, MT, exposure to amphibole-containing vermiculite was linked to increased rates of asbestosis, lung cancer, and mesothelioma. Although many studies showed adverse effects following exposure to Libby amphibole (LA; a mixture of winchite, richterite, and tremolite), little is known regarding the relative toxicity of LA compared to regulated asbestos, or regar...

 

Author information

 

  1. Bar-Ilan University, Ramat-Gan, Israel.

Abstract

 

Radical-scavenging antioxidants, as part of the cellular defense system, function to inhibit the formation and propagation of free radicals and active oxygen species formation. In previous studies we demonstrated that endotoxin lipopolysaccharide (LPS) promotes oxidative stress and associated pathological changes in a rat model and that use of selected antioxidants was effective in reducing LPS-related lipid peroxidation product formation in the liver, as well...

 

Author information

 

  1. Global Pathology Support, The Hague, The Netherlands. bob.thoolen@gpstoxpath.com

Abstract

 

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to pr...

  1. Experimental Pathology Laboratories, PO Box 12766, Research Triangle Park, NC 27709, USA. brix@niehs.nih.gov

Abstract

 

The NTP has a long history of using Fischer rats and has compiled a large database of incidences of lesions seen in control animals. Such a database is lacking for Harlan Sprague-Dawley (SD) rats. The intention of this paper is to report spontaneous lesions observed in female vehicle control Harlan SD rats, and to compare the incidence in 2 strains of rats (Fischer and Harlan SD) used in NTP studies. Female Harla...

Author information

  1. Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

  2. Juvenis Ltd., M. P Misgav, Israel.

  3. Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel.

  4. Tel Aviv University and consultant in toxicologic pathology, Timrat, Tel Aviv, Israel anyska@bezeqint.net.

Abstract

Soft tissue filler products have become very popular in recent years, with ever-increasing medical and aesthetic indications. While generally considered...

Authors

 

Abraham Nyska,Yael S. Schiffenbauer, Catherine T. Brami2, Robert R. Maronpot3 and

Yuval Ramot

 

Abstract

 

Toxicologic pathology is the art of assessment of potential adverse effects at the tissue level in pre-clinical studies. In the case of biomaterials and medical devices, the toxicologic pathologists assess the safety (biocompatibility) and efficacy (conditions of the use) of the implantable materials. Proper assessment of biocompatibility of biomaterials is of utmost importance, since it helps to determine their safety af...

 

Toxicologic pathology is the art of assessment of potential adverse effects at the tissue level in pre-clinical studies. In the case of biomaterials and medical devices, the toxicologic pathologists assess the safety (biocompatibility) and efficacy (conditions of the use) of the implantable materials. Proper assessment of biocompatibility of biomaterials is of utmost importance, since it helps to determine their safety after implantation in humans. Biomaterial-related toxicity can be attributed to several factors, including for examp...

 

Author information

 

  1. National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA ridercv@niehs.nih.gov.

  2. Integrated Laboratory Systems Incorporated, Research Triangle Park, Durham, North Carolina, USA.

  3. National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA.

  4. Battelle, Columbus, Ohio, USA.

  5. Charles River Laboratories, Pathology Associates, Durham, North Carolina, USA.

Abstract

 

Ginkgo biloba extract (GBE) is a popular her...

Author information

 

  1. Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, NC 27519, USA. hoenerhm@niehs.nih.gov

Abstract

 

Ginkgo biloba leaf extract (GBE) has been used for centuries in traditional Chinese medicine and today is used as an herbal supplement touted for improving neural function and for its antioxidant and anticancer effects. Herbal supplements have the potential for consumption over extended periods of time, with a genera...

Toxicol Pathol. 2013 Aug;41(6):826-41. doi: 10.1177/0192623312467520. Epub 2012 Dec 21.

 

Author information

  1. Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, NC 27519, USA. hoenerhm@niehs.nih.gov

Abstract

 

Ginkgo biloba leaf extract (GBE) has been used for centuries in traditional Chinese medicine and today is used as an herbal supplement touted for improving neural function and for its antioxidant and anticancer effects. Herbal supp...

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