Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.
Author information Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA. bonnerj@niehs.nih.gov Abstract The cyclooxygenase (COX)-2 enzyme has been implicated as an important mediator of pulmonary fibrosis. In this study, the lung fibrotic responses were investigated in COX-1 or COX-2-deficient (-/-) mice following vanadium pentoxide (V(2)O(5)) exposure. Lung h
Systemic vascular disease in male B6C3F1 mice exposed to particulate matter by inhalation: studies c
Author information Pathology Associates, Raleigh, North Carolina 27606, USA. Abstract Epidemiological studies suggest an association between ambient particulate matter and cardiopulmonary diseases in humans. The mechanisms underlying these health effects are poorly understood. To better understand the potential relationship between particulate-matter-induced inflammation and vascular disease, a 2-phase retrospective study was conducted. Phase one included the review of heart,