Author information Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Juvenis Ltd., M. P Misgav, Israel. Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel. Tel Aviv University and consultant in toxicologic pathology, Timrat, Tel Aviv, Israel anyska@bezeqint.net. Abstract Soft tissue filler products have become very popular in recent years, with ever-increasing medical and aesthetic

Authors Abraham Nyska,Yael S. Schiffenbauer, Catherine T. Brami2, Robert R. Maronpot3 and Yuval Ramot Abstract Toxicologic pathology is the art of assessment of potential adverse effects at the tissue level in pre-clinical studies. In the case of biomaterials and medical devices, the toxicologic pathologists assess the safety (biocompatibility) and efficacy (conditions of the use) of the implantable materials. Proper assessment of biocompatibility of biomaterials is of utmost

Toxicologic pathology is the art of assessment of potential adverse effects at the tissue level in pre-clinical studies. In the case of biomaterials and medical devices, the toxicologic pathologists assess the safety (biocompatibility) and efficacy (conditions of the use) of the implantable materials. Proper assessment of biocompatibility of biomaterials is of utmost importance, since it helps to determine their safety after implantation in humans. Biomaterial-related toxicit

Author information Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel. Abstract We have generated a mouse that cannot synthesize very long acyl chain (C22-C24) ceramides (Pewzner-Jung, Y., Park, H., Laviad, E. L., Silva, L. C., Lahiri, S., Stiban, J., Erez-Roman, R., Brugger, B., Sachsenheimer, T., Wieland, F. T., Prieto, M., Merrill, A. H., and Futerman, A. H. (2010) J. Biol. Chem. 285, 10902-10910) due to ablation of ceramide synthase 2

Author information National Health and Environmental Effects Research Laboratory, ORD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Gordon.christopher@epa.gov Abstract Aging adults are a growing segment of the U.S. population and are likely to exhibit increased susceptibility to many environmental toxicants. However, there is little information on the susceptibility of the aged to toxicants. The toxicity of toluene has been well character

Author information Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada. Abstract Human cytochrome P-450 (CYP)2J2 is abundant in heart and active in biosynthesis of epoxyeicosatrienoic acids (EETs). Recently, we demonstrated that these eicosanoid products protect myocardium from ischemia-reperfusion injury. The present study utilized transgenic (Tr) mice with cardiomyocyte-specific overexpression of human CYP2J2 to investigate prot

Author information Experimental Toxicology Division, National Health & Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. Abstract BACKGROUND: Exposure to diesel exhaust (DE) is linked to vasoconstriction, endothelial dysfunction, and myocardial ischemia in compromised individuals. OBJECTIVE: We hypothesized that DE inhalation would cause greater inflammation, hemato

Author information Department of Orthopaedic Surgery, Meir Medical Center, 48 Tchernichovsky Str., Kfar-Saba 44281, Israel. yaronbrin@gmail.com Abstract We evaluated the potential of an injectable degradable polymer-poly(sebacic-co-ricinoleic-ester-anhydride) containing gentamicin for the treatment of osteomyelitis. Osteomyelitis of both tibiae was induced in 13 female Fischer rats by injecting a suspension containing approximately 105 (CFU)/ml of S. aureus into the tibial me

Department of Orthopaedic Surgery, Meir Medical Center, 48 Tchernichovsky Str.,Kfar-Saba 44281, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel Department of Medicinal Chemistry and Natural Products, School of Pharmacy,The Hebrew University of Jerusalem, Jerusalem 91120, Israel Department of Parasitology, The Kuvin Centre for the Study of Infectious and Tropical Diseases, The Hebrew University of Jerusalem, Jerusalem 91120, Israel Abstract We ev

Author information Department of Pathology, Tufts-New England Medical Center, Boston, MA 02111, USA. jpowers1@tufts-nemc.org Abstract Pheochromocytomas are catecholamine-producing tumors of the adult adrenal medulla. They are rare in humans and most other species but common in laboratory rats. However, the relevance of rat pheochromocytomas as a model for their human counterparts is uncertain. Previous studies of spontaneous and drug-induced rat pheochromocytomas and the PC12