Abraham Nyska

DVM, Dipl. ECVP, Fellow IATP Expert in Toxicologic Pathology

 

 

  • Home

  • Bio Sketch and CV

  • Publications

  • Lectures

  • Awards in USA

  • Professional Links

  • Family

  • Contact

  • More

    Comparative long-term toxicity of Libby amphibole and amosite asbestos in rats after single or multiple intratracheal exposures.

    September 30, 2015

    The prophylactic effects of natural water-soluble antioxidant from spinach and apocynin in a rabbit model of lipopolysaccharide-induced endotoxemia.

    June 25, 2015

    Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system.

    June 6, 2015

    Incidences of selected lesions in control female Harlan Sprague-Dawley rats from two-year studies performed by the National Toxicology Program.

    May 25, 2015

    Interspecies Differences in Reaction to a Biodegradable Subcutaneous Tissue Filler: Severe Inflammatory Granulomatous Reaction in the Sinclair Minipig

    May 26, 2014

    Please reload

    Recent Posts
    Featured Posts

    Interspecies Differences in Reaction to a Biodegradable Subcutaneous Tissue Filler: Severe Inflammatory Granulomatous Reaction in the Sinclair Minipig

    May 26, 2014

    |

    Ramot Y(1), Touitou D(2), Levin G(2), Ickowicz DE3, Zada MH3, Abbas R(2), Yankelson L(2), Domb AJ(3), Nyska A(4).

    Author information

    1. Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

    2. Juvenis Ltd., M. P Misgav, Israel.

    3. Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel.

    4. Tel Aviv University and consultant in toxicologic pathology, Timrat, Tel Aviv, Israel anyska@bezeqint.net.

    Abstract

    Soft tissue filler products have become very popular in recent years, with ever-increasing medical and aesthetic indications. While generally considered safe, the number of reported complications with tissue fillers is growing. Nevertheless, there is no specific animal model that is considered as the gold standard for assessing safety or efficacy of tissue fillers, and there are very little data on interspecies differences in reaction to these products. Here, we report on interspecies differences in reaction to a subcutaneous injectable co-polyester, composed of castor oil and citric acid. Comparison of the histopathological local tissue changes following 1-month postimplantation, indicated that in rats the reaction consisted of cavities, surrounded by relatively thin fibrotic enveloping capsule. In contrast, an unexpected severe inflammatory granulomatous reaction was noticed in Sinclair minipigs. To our knowledge, this is the first report on significant interspecies differences in sensitivity to tissue fillers. It emphasizes the importance of using the appropriate animal model for performing preclinical biocompatibility assays for biodegradable polymers, tissue fillers, and implanted medical devices in general. It also makes the Sinclair minipig subject for scrutiny as an animal model in future biocompatibility studies

     

    download

     

    Tags:

    Biocompatibility Studies

    Please reload

    Follow Us

    Biocompatibility Studies

    Gene Expression In Diseases

    Herbal medicine safety assessment

    Preclinical Safety Assessment

    Please reload

    Search By Tags

    September 2015 (1)

    June 2015 (2)

    May 2015 (1)

    May 2014 (3)

    August 2013 (3)

    July 2013 (1)

    May 2013 (1)

    April 2013 (1)

    February 2013 (2)

    December 2012 (1)

    September 2012 (1)

    May 2012 (1)

    January 2012 (1)

    November 2011 (1)

    September 2011 (2)

    August 2011 (1)

    May 2011 (1)

    March 2011 (1)

    October 2010 (1)

    September 2010 (2)

    April 2010 (1)

    January 2010 (1)

    December 2009 (1)

    May 2009 (3)

    January 2009 (1)

    October 2008 (1)

    May 2008 (2)

    April 2008 (1)

    January 2008 (1)

    August 2007 (2)

    January 2007 (1)

    November 2006 (1)

    February 2005 (1)

    November 2003 (1)

    May 2003 (1)

    February 2003 (1)

    January 2003 (1)

    November 2002 (1)

    August 2002 (2)

    July 2002 (1)

    March 2002 (1)

    February 2002 (1)

    November 2001 (1)