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Biocompatibility of a Polymeric Implant for the Treatment of Osteomyelitis

  1. Department of Orthopaedic Surgery, Meir Medical Center, 48 Tchernichovsky Str.,Kfar-Saba 44281, Israel

  2. Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

  3. Department of Medicinal Chemistry and Natural Products, School of Pharmacy,The Hebrew University of Jerusalem, Jerusalem 91120, Israel

  4.  Department of Parasitology, The Kuvin Centre for the Study of Infectious and Tropical Diseases, The Hebrew University of Jerusalem, Jerusalem 91120, Israel

Abstract

 

We evaluated the biocompatibility of an injectable gelling polymeric device for the controlled release

of gentamicin sulfate in the treatment of invasive bacterial infections in bone of male Wister rats. The

biodegradable delivery carrier, poly(sebacic-co-ricinoleic-ester-anhydride), designated as p(SA:RA), was

injected, with and without gentamicin, into the tibial canal. Rats were killed 3 weeks later. The tibiae were

processed histologically, leaving the injectable polymer in situ. The local tissue reaction to the polymer with

or without antibiotic consisted mainly of mild reactive fibroplasia/fibrosis and mild to moderate increased

reactive bone formation. At this stage, no evidence for any active inflammatory response to the polymer

was seen. Thus, the injection of p(SA:RA) was well tolerated and did not induce any signs of a progressive

inflammatory reaction.

© Koninklijke Brill NV, Leiden, 2009

 

Keywords

Biocompatible degradable polymer, tibial implant, toxicity evaluation, controlled delivery, gentamicin

 

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