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Electrocoating of stainless steel coronary stents for extended release of paclitaxel

  1. Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel

  2. Department of Inorganic and Analytical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

  3. Expert in Toxicologic Pathology, Sackler School of Medicine, Tel Aviv University, Timrat 36576, Israel

  4. AQ2 National Institute for Pharmaceutical Research (NIPER), New Delhi, India

Abstract: Nonbiodegradable polymer coating based on N-(2-carboxyethyl)pyrrole (PPA) and butyl ester of PPA (BuOPy) were successfully electrodeposited on a stainless steel stent surface using cyclic voltammetry. Chemical composition

of the coating was examined by X-ray photoelectron spectroscopy. Polymer stability was examined by immersing the coated stent into 1:1 solution of fetal calf serum:seline solution

up to 1 year and implantation subcutaneously in mouse for 1 week. Morphology changes were then recorded by scanning electron microscopy. Paclitaxel loading was carried out by immersion into drug solution and its release was detected by HPLC. The results show that thin (single micrometers), uniform coating with various morphology and hydrophobicity can be created by electrochemical deposition. The polymer did not show significant histopathological or  morphological changes in vitro and in vivo. The surface properties allow loading appropriate amounts of paclitaxel  and release it slowly up to a month.  2008 Wiley Periodicals, Inc. J Biomed Mater Res 00A: 000–000, 2008 Key words: pyrrole; electrocoating; stainless steel; stent;

local drug delivery.

 

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