Abraham Nyska

DVM, Dipl. ECVP, Fellow IATP Expert in Toxicologic Pathology

 

 

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    Comparative long-term toxicity of Libby amphibole and amosite asbestos in rats after single or multiple intratracheal exposures.

    September 30, 2015

    The prophylactic effects of natural water-soluble antioxidant from spinach and apocynin in a rabbit model of lipopolysaccharide-induced endotoxemia.

    June 25, 2015

    Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system.

    June 6, 2015

    Incidences of selected lesions in control female Harlan Sprague-Dawley rats from two-year studies performed by the National Toxicology Program.

    May 25, 2015

    Interspecies Differences in Reaction to a Biodegradable Subcutaneous Tissue Filler: Severe Inflammatory Granulomatous Reaction in the Sinclair Minipig

    May 26, 2014

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    Effects of antioxidants apocynin and the natural water-soluble antioxidant from spinach on cellular damage induced by lipopolysaccaride in the rat.

    July 31, 2000

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    Lomnitski L1, Nyska A, Ben-Shaul V, Maronpot RR, Haseman JK, Harrus TL, Bergman M, Grossman S.

     

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    1. Bar-Ilan University, Ramat-Gan, Israel.

    Abstract

     

    Oxidative damage plays a key role in septic shock induced by the endotoxin lipopolysaccaride (LPS) by enhancing the formation of reactive oxygen species such as superoxide anion radicals, peroxides, and their secondary product, malondialdehyde, especially in the liver. In this study, histopathologic changes in several organs were compared among groups of male Wistar rats that had been injected with LPS following prophylactic pretreatment with either of 2 antioxidants, a group that had been injected with LPS without pretreatment with antioxidants, an untreated control group, and groups that had been injected with either of the 2 antioxidants only. The antioxidants used were a water-soluble natural antioxidant from spinach (NAO) and the NADPH oxidase inhibitor apocynin. Hematoxylin-and-eosin-stained slides were prepared, and lesions were semiquantitatively scored. Exposure to LPS alone was associated with multifocal hepatocellular necrosis and acute inflammation, thymic and splenic lymphoid necrosis, ocular retinal hemorrhage and acute endophthalmitis, adrenal medullary vacuolation and necrosis and acute inflammation, and decreased adrenal cortical cytoplasmic vacuolation (consistent with depletion of steroidal hormone contents). Results indicated that pretreatment with both antioxidants for 8 days reduced, in some organs, the necrotic and inflammatory changes associated with the LPS challenge. These findings suggest a potential therapeutic application for these antioxidants in clinical sepsis.

     

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