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  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. dunnickj@niehs.nih.gov

Abstract

 

Ma Huang (equivalent to 0, 12.5, 25, or 50 mg/kg ephedrine) or ephedrine (0, 6.25, 12.5, 25 mg/kg) were administered as one bolus oral dose to male F344 rats with and without caffeine. The herbal medicine Ma Huang (ephedra) in combination with caffeine caused rapid clinical signs of toxicity including salivation, hyperactivity, ataxia, and eventually lethargy, and failure to respond to stimuli....

  1. Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel

  2. Department of Inorganic and Analytical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

  3. Expert in Toxicologic Pathology, Sackler School of Medicine, Tel Aviv University, Timrat 36576, Israel

  4. AQ2 National Institute for Pharmaceutical Research (NIPER), New Delhi, India

Abstract: Nonbiodegradable polymer coating based on N-(2-carboxyethyl)py...

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